Functional nutrition, clinical nutricosmetics, and applied epigenetics to reprogram your biology, optimize your metabolism, and activate cellular longevity.
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Skin aging is inevitable, but science has recently discovered that it is not a process completely outside of our control. Recent studies, such as the article "Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight," reveal that our DNA has "epigenetic switches" that regulate how our cells behave over time.
When these switches are altered—by stress, sun exposure, pollution, or simply the passing of years—fibroblasts, the cells responsible for maintaining skin firmness and elasticity, begin to deteriorate. This leads to wrinkles, collagen loss, skin thinning, and a reduced capacity for regeneration and defense against external agents.
One of the key players in this process is the enzyme DNMT1, which helps maintain the balance of gene expression. Its decline with age contributes to "epigenetic chaos," accelerating skin aging.
The good news: Science has also identified tools to modulate these processes and "reprogram" the skin toward a healthier state. These compounds, known as geroprotectors, help maintain cellular homeostasis and delay the skin's biological clock.
Key Scientific Insights for Skin Care:
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NAD+ and its precursors (NMN, NR): Restore cellular energy, repair DNA, and delay senescence.
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N-acetyl-L-cysteine (NAC): A powerful antioxidant that protects the skin from oxidative damage and regulates gene expression.
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Antioxidants like resveratrol, green tea, blue tea, and spirulina: Combat oxidative stress and promote cellular longevity.
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Curcuminoids: Offer anti-inflammatory and regenerative effects, modulating the enzymes that regulate gene expression.
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$\beta$-glucans from Ganoderma lucidum (Reishi): Enhance the skin's immune response, promote healing, and protect against accelerated aging.
Arum and the Science of Cellular Care:
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ARUM DFS: With N-acetyl-L-cysteine and turmeric extract to regulate inflammation and protect cellular balance.
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ARUM Fresh: With resveratrol, green tea, blue tea, and spirulina for a powerful antioxidant effect.
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ARUM Life: With Verisol® collagen peptides that promote skin firmness and elasticity. And coming soon to the USA, a new version enriched with NAD+ to boost cellular bioenergetics!
Conclusion:
The combination of healthy habits, bioactive ingredients, and scientifically backed nutriceuticals can modulate epigenetic processes, delaying aging and helping your skin look firmer, more radiant, and younger for longer.
Reference
Pozzo LD, et al. Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight. Biomed Pharmacother. 2024 May;174:116592.
Based on the scientific information regarding cutaneous epigenetics and ARUM's own resources (advanced nutricosmetics, holistic protocols, and support for aesthetic professionals), we propose an Integral Epigenetic Repair Protocol applicable to cosmetologists, aestheticians, cosmiatras, and aesthetic physicians.
Perfect 🙌 We'll prepare an ARUM Operational Protocol for Epigenetic Repair in a practical checklist format for cosmetologists, aestheticians, cosmiatras, and aesthetic physicians to apply directly in their clinic and for nutritional follow-up.
✅ ARUM Operational Protocol – Epigenetic Repair
1. Initial Assessment (Day 0)
Aesthetic and metabolic clinical history.
Identification of risk factors: smoking, stress, high-sugar diet, sun exposure.
Skin and tissue diagnosis: wrinkles, spots, sagging, scars, cellulite.
Define the aesthetic procedure (facial, corporal, devices, injectables).
2. Epigenetic Preparation Phase (7-14 days before)
Daily Nutricosmetics:
ARUM Fresh → 1 daily dose. Antioxidants (resveratrol, green tea, blue tea, spirulina) → activates longevity genes.
ARUM DFS → 1 daily dose. NAC + turmeric → regulates inflammation and reprograms DNMT1.
ARUM Life → 1 daily dose. Verisol® collagen peptides → stimulates fibroblasts and dermal matrix.
Lifestyle Recommendations:
Hydration 2-3 L/day.
Restorative sleep 7-8 hrs.
Reduction of alcohol, sugars, and processed foods.
Daily facial cleansing routine + sun protection.
3. Procedure Session (Cabin/Consultation)
Prior to Session (30 min before):
Ingestion of ARUM Fresh + ARUM Life.
During the Session (according to goal):
Apply chosen equipment/device:
Radiofrequency → collagen and elastin.
LED (red/blue) → cellular repair and anti-inflammatory.
Plasma / microneedling → deep regeneration.
Integrate virtual mesotherapy/topical antioxidants (green tea, reishi, topical turmeric) if applicable.
Immediate Post-treatment:
Cold antioxidant compresses.
Ingestion of ARUM DFS to modulate inflammation.
4. Maintenance Phase (8 weeks)
Continuous Nutricosmetics:
ARUM Fresh → daily.
ARUM Life → daily.
ARUM DFS → cycles of 2-3 weeks, especially after aggressive treatments.
External Sessions:
1 weekly non-invasive stimulation session (RF, LED, biostimulation).
Habits:
Anti-inflammatory diet (fruits, vegetables, omega-3).
Moderate exercise 3-4 times/week.
Stress management practices (breathing, meditation).
5. Expected Results (8 weeks)
✔ Reduction of wrinkles and fine lines.
✔ Increased firmness and elasticity (active fibroblasts).
✔ Luminosity and uniform tone.
✔ Accelerated repair after laser, peeling, or plasma.
✔ Improvement in cellulite and body sagging.
✔ Potentiation of the duration and effectiveness of botulinum toxin, threads, and fillers.
🔑 Epigenetic Correction Achieved:
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Reversal of epigenetic chaos (NAC + turmeric → DNMT1).
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Activation of longevity genes (resveratrol → SIRT1).
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Sustained stimulation of fibroblasts (Verisol® collagen).
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Immune modulation and detoxification ($\beta$-glucans, antioxidants).